Which is a contraindication for the administration of tissue plasminogen activator (t-pa)?11/8/2022 These consequences deprive the brain of necessary oxygen which result in permanent brain cell death in and around the affected area. Sometimes blood clot forms in the heart and get trapped in the brain’s narrow arteries (cerebral stroke). An ischemic stroke can occur as a result of a barrier within a blood vessel supplying blood to the brain (thromblic stroke) or embolus produced from clot somewhere else in the body and travels to block a small artery in the brain (embolic stroke). Blood clots may also disrupt the flow of blood to the brain, leading to an ischemic stroke. Cardiac ischemia appears when blood flow to cardiac muscle becomes fully or partially restricted resulting shortness of breath, syncope, angina, myocardial infarction, cardiac arrhythmia, or even death. Blood clot can block blood flow or oxygen to tissue which results in ischemia. For example, a pulmonary embolism leads inexplicable breathing difficulty, hemoptysis, and chest pain when one or more arteries in lung are blocked by embolus. Embolism occurs when blood clot is formed inside a blood vessel or an artery and remains there which fully or partially block blood supply to a part of body resulting potentially severe consequences. If thrombus is formed when it is not needed, this can produce significant consequences like embolism, ischemia, heart attack, stroke, and so forth. IntroductionĪ blood clot (thrombus) develops in the circulatory system which consolidates a mechanism in human body to repair the injured blood vessel. In these review we discussed about these aspect of thrombolytic therapy. Besides proper knowledge of contraindication, evolutionary factor, and combination of drug is essential for successful thrombolytic therapy. These cares include preinfusion care, during the infusion care, and postinfusion care. Thrombolytic therapy should be given with maintaining proper care in order to minimize the risk of clinically important bleeding as well as enhance the chances of successfully thrombolysis of clot. Now day’s different types of thrombolytic drugs are currently available in market: alteplase, anistreplase, urokinase, streptokinase, tenecteplase, and so forth. In 1761, Morgagni lead the way of thrombolytic therapy. It has been used in the clinical area to treat venous and arterial thromboembolic complaints which are a foremost cause of death. Thrombolytic therapy, also known as clot busting drug, is a breakthrough treatment which has saved untold lives.
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